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  • Superoxide dismutase-3 promotes full expression of the

    2004-7-1u2002·u2002Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia ... but its distribution and biologic functions there are unknown. To investigate the function of renal SOD3, we colocalized it with erythropoietin (EPO) to proximal tubules using in situ hybridization and immunohistochemistry. ... by cutting the cortex into small ...

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  • Therapeutic potentials of superoxide dismutase

    2 days agou2002·u2002Introduction. Superoxide dismutases (SODs) are a group of metalloenzymes that are found in all kingdoms of life. SODs form the front line of defense against reactive oxygen species (ROS)-mediated injury.[] These proteins catalyze the dismutation of superoxide anion free radical (O 2-) into molecular oxygen and hydrogen peroxide (H 2 O 2) [Figure 1a] and decrease O 2-level which …

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  • The Adventures of Superoxide Dismutase in Health and ...

    Xu, Y., Porntadavity, S., and St Clair, D. K. (2002). Transcriptional regulation of the human manganese superoxide dismutase gene: the role of specificity protein 1 (Sp1) and activating protein-2 (AP-2). Biochem J 362, 401–412. PubMed CrossRef Google Scholar

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  • Modifications of Superoxide Dismutase (SOD1) in Human ...

    Over 100 mutations in Cu/Zn-superoxide dismutase (SOD1) result in familial amyotrophic lateral sclerosis. Dimer dissociation is the first step in SOD1 aggregation, and studies suggest nearly every amino acid residue in SOD1 is dynamically connected to the dimer interface. Post-translational modifications of SOD1 residues might be expected to have similar effects to mutations, but few ...

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  • Modifications of superoxide dismutase (SOD1) in human ...

    2009-3-19u2002·u2002Familial amyotrophic lateral sclerosis (FALS) 4 is the hereditary form of amyotrophic lateral sclerosis, a fatal disease characterized by progressive motor neuron loss ().A subset of FALS is caused by mutations in the gene encoding homodimeric Cu/Zn-superoxide dismutase (SOD1), which forms intraneuronal aggregates ().Although SOD1 aggregation is involved in SOD1-mediated FALS, it is …

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  • Modifications of Superoxide Dismutase (SOD1) in Human ...

    2009-5-15u2002·u2002SOD1 Is Modified in Human Erythrocytes—Using a 12-tesla FT-ICR-MS with ultrahigh mass accuracy and resolution, full-length wild-type SOD1 from human erythrocytes was found to have a monoisotopic mass of 15837.8902 Da (Fig. 1A), corresponding to the theoretical mass of 15837.8812 Da for N-terminal acetylated wild-type human SOD1.In addition to the acetylated form, two strong peaks …

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  • Biochemical Aspects of Superoxide Dismutase Isolated

    2014-5-20u2002·u2002Biochemical Aspects of Superoxide Dismutase Isolated from Amaranthus spinosus: A Therapeutically Important Plant S Sharma, S Bahuguna, N Kaur and N Chaudhary Amity Institute of Biotechnology, Amity University Uttar Pradesh Sector-125, Noida-201303, India Abstract Superoxide dismutase (SOD, EC 1.15.1.1), an ubiquitous potent

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  • (PDF) Superoxide dismutase-3 promotes full expression of ...

    Extracellular superoxide dismutase (SOD3) is the primary extracellular enzymatic scavenger of superoxide ((.)O(2)(-)). SOD3's expression is highest in the kidney, but its distribution and biologic ...

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  • rrv nt io Research - Longdom

    2019-4-18u2002·u2002human Umbilical Vein Endothelium) in vitro, protects catalase and superoxide dismutase when prepared using nanosecond pulsed electric fields rather than bovine thrombin and decreases the metalloproteinase MMP-2 and increases the metalloproteinase inhibitor TIMP-1 in H9c2 cells (Rattus norvegicus. H9c2 cardiac myoblast cells) in vitro. Introduction

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  • Extracellular Superoxide Dismutase: Growth Promoter or ...

    2016-5-12u2002·u2002Extracellular superoxide dismutase (SOD3) gene transfer to tissue damage results in increased healing, increased cell proliferation, decreased apoptosis, and decreased inflammatory cell infiltration. At molecular level, in vivo SOD3 overexpression reduces superoxide anion () concentration and increases mitogen kinase activation suggesting that ...

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  • Modifications of Superoxide Dismutase (SOD1) in Human ...

    Over 100 mutations in Cu/Zn-superoxide dismutase (SOD1) result in familial amyotrophic lateral sclerosis. Dimer dissociation is the first step in SOD1 aggregation, and studies suggest nearly every amino acid residue in SOD1 is dynamically connected to the dimer interface. Post-translational modifications of SOD1 residues might be expected to have similar effects to mutations, but few ...

    Get Price
  • Superoxide Dismutase (Ransod) Quality Control - Randox ...

    A dedicated Superoxide Dismutase quality control for use in the routine monitoring of the Randox Ransod assay on clinical chemistry analysers.

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  • Modifications of Superoxide Dismutase (SOD1) in Human ...

    2009-5-15u2002·u2002SOD1 Is Modified in Human Erythrocytes—Using a 12-tesla FT-ICR-MS with ultrahigh mass accuracy and resolution, full-length wild-type SOD1 from human erythrocytes was found to have a monoisotopic mass of 15837.8902 Da (Fig. 1A), corresponding to the theoretical mass of 15837.8812 Da for N-terminal acetylated wild-type human SOD1.In addition to the acetylated …

    Get Price
  • Biochemical Aspects of Superoxide Dismutase Isolated from ...

    2014-5-20u2002·u2002Biochemical Aspects of Superoxide Dismutase Isolated from Amaranthus spinosus: A Therapeutically Important Plant S Sharma, S Bahuguna, N Kaur and N Chaudhary Amity Institute of Biotechnology, Amity University Uttar Pradesh Sector-125, Noida-201303, India Abstract Superoxide dismutase (SOD, EC 1.15.1.1), an ubiquitous potent

    Get Price
  • Extracellular Superoxide Dismutase: Growth Promoter or ...

    2016-5-12u2002·u2002Extracellular superoxide dismutase (SOD3) gene transfer to tissue damage results in increased healing, increased cell proliferation, decreased apoptosis, and decreased inflammatory cell infiltration. At molecular level, in vivo SOD3 overexpression reduces superoxide anion () concentration and increases mitogen kinase activation suggesting that ...

    Get Price
  • (PDF) Superoxide dismutase-3 promotes full expression of ...

    Extracellular superoxide dismutase (SOD3) is the primary extracellular enzymatic scavenger of superoxide ((.)O(2)(-)). SOD3's expression is highest in the kidney, but its distribution and biologic ...

    Get Price
  • Perfluorochemical Liquids Enhance Delivery of Superoxide ...

    2006-7-1u2002·u2002Langenback EG, Davis JM, Robbins C, Sahgal N, Perry RJ, Simon SR 1999 Improved pulmonary distribution of recombinant human Cu/Zn superoxide dismutase, using a modified ultrasonic nebulizer ...

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  • rrv nt io Research - Longdom

    2019-4-18u2002·u2002human Umbilical Vein Endothelium) in vitro, protects catalase and superoxide dismutase when prepared using nanosecond pulsed electric fields rather than bovine thrombin and decreases the metalloproteinase MMP-2 and increases the metalloproteinase inhibitor TIMP-1 in H9c2 cells (Rattus norvegicus. H9c2 cardiac myoblast cells) in vitro. Introduction

    Get Price
  • Superoxide Dismutase 1 Nanozyme for Treatment of Eye ...

    2015-12-1u2002·u2002Use of antioxidants to mitigate oxidative stress during ocular inflammatory diseases has shown therapeutic potential. This work examines a nanoscale therapeutic modality for the eye on the base of antioxidant enzyme, superoxide dismutase 1 (SOD1), termed 'nanozyme.' The nanozyme is produced by electrostatic coupling of the SOD1 with a cationic block copolymer, …

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  • Eukaryotic copper-only superoxide dismutases (SODs): A new ...

    2018-3-30u2002·u2002The copper-containing superoxide dismutases (SODs) represent a large family of enzymes that participate in the metabolism of reactive oxygen species by disproportionating superoxide anion radical to oxygen and hydrogen peroxide. Catalysis is driven by the redox-active copper ion, and in most cases, SODs also harbor a zinc at the active site that enhances copper …

    Get Price
  • Modifications of Superoxide Dismutase (SOD1) in Human ...

    Over 100 mutations in Cu/Zn-superoxide dismutase (SOD1) result in familial amyotrophic lateral sclerosis. Dimer dissociation is the first step in SOD1 aggregation, and studies suggest nearly every amino acid residue in SOD1 is dynamically connected to the dimer interface. Post-translational modifications of SOD1 residues might be expected to have similar effects to mutations, but few ...

    Get Price
  • Extracellular Superoxide Dismutase Protects Histoplasma ...

    2012-5-17u2002·u2002Author Summary Histoplasma capsulatum is a fungal pathogen that is endemic to the Mississippi and Ohio River valleys. An estimated 200,000 infections occur annually in the United States. Histoplasma is adept at surviving within both neutrophils and macrophages, which normally kill fungal cells by producing reactive oxygen molecules that are toxic to microbes.

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  • rrv nt io Research - Longdom

    2019-4-18u2002·u2002human Umbilical Vein Endothelium) in vitro, protects catalase and superoxide dismutase when prepared using nanosecond pulsed electric fields rather than bovine thrombin and decreases the metalloproteinase MMP-2 and increases the metalloproteinase inhibitor TIMP-1 in H9c2 cells (Rattus norvegicus. H9c2 cardiac myoblast cells) in vitro. Introduction

    Get Price
  • Placental superoxide dismutase 3 mediates benefits of ...

    2021-5-4u2002·u2002Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health Author links open overlay panel Joji Kusuyama 1 2 Ana Barbara Alves-Wagner 1 Royce H. Conlin 1 Nathan S. Makarewicz 1 Brent G. Albertson 1 Noah B. Prince 1 Shio Kobayashi 3 Chisayo Kozuka 1 4 Magnus Møller 5 Mette Bjerre 6 Jens Fuglsang 5 Emily Miele 1 ...

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  • Perfluorochemical Liquids Enhance Delivery of Superoxide ...

    2006-7-1u2002·u2002Langenback EG, Davis JM, Robbins C, Sahgal N, Perry RJ, Simon SR 1999 Improved pulmonary distribution of recombinant human Cu/Zn superoxide …

    Get Price
  • Cupric Ions Induce the Oxidation and Trigger the ...

    2013-6-3u2002·u2002Background Amyotrophic lateral sclerosis (ALS), partly caused by the mutations and aggregation of human copper, zinc superoxide dismutase (SOD1), is a fatal degenerative disease of motor neurons. Because SOD1 is a major copper-binding protein present at relatively high concentration in motor neurons and copper can be a harmful pro-oxidant, we want to know whether aberrant copper …

    Get Price
  • Eukaryotic copper-only superoxide dismutases (SODs): A

    2018-3-30u2002·u2002The copper-containing superoxide dismutases (SODs) represent a large family of enzymes that participate in the metabolism of reactive oxygen species by disproportionating superoxide anion radical to oxygen and hydrogen peroxide. Catalysis is driven by the redox-active copper ion, and in most cases, SODs also harbor a zinc at the active site that enhances copper catalysis and stabilizes the ...

    Get Price
  • Superoxide Dismutase 1 Nanozyme for Treatment of Eye ...

    2015-12-1u2002·u2002Use of antioxidants to mitigate oxidative stress during ocular inflammatory diseases has shown therapeutic potential. This work examines a nanoscale therapeutic modality for the eye on the base of antioxidant enzyme, superoxide dismutase 1 (SOD1), termed 'nanozyme.' The nanozyme is produced by electrostatic coupling of the SOD1 with a cationic block copolymer, poly(L-lysine)-poly ...

    Get Price
  • Identification of biomarkers for the antiangiogenic and ...

    2008-2-5u2002·u2002Superoxide dismutase 3 activity in human plasma is low, but increases upon treatment with heparin (Tasaki et al, 2006). Blood from laboratory personnel who had volunteered for …

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  • Total Antioxidant Capacity (TAC) Assay - Cell Biolabs

    2021-9-27u2002·u2002The OxiSelect™ Total Antioxidant Capacity (TAC) Assay measures the total antioxidant capacity of biomolecules from a variety of samples via a SET mechanism. In the presence of antioxidants, copper(II) is reduced to copper(I). In turn, the copper(I) ions react with a chromogen to produce a color with maximum absorbance at 490nm.

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  • The biophysics of superoxide dismutase-1 and

    Human and bovine SOD1 were each found to be composed of two sub-units of 16 kDa with strong interactions. This indicated that SOD1 is dimeric with high dimer affinity (Keele et al., Reference Keele, McCord and Fridovich 1971; Hartz and Deutsch, Reference …

    Get Price
  • Identification of biomarkers for the antiangiogenic and ...

    2008-2-5u2002·u2002Superoxide dismutase 3 activity in human plasma is low, but increases upon treatment with heparin (Tasaki et al, 2006). Blood from laboratory personnel who had volunteered for …

    Get Price
  • Placental superoxide dismutase 3 mediates benefits of ...

    2021-5-4u2002·u2002Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health Author links open overlay panel Joji Kusuyama 1 2 Ana Barbara Alves-Wagner 1 Royce H. Conlin 1 Nathan S. Makarewicz 1 Brent G. Albertson 1 Noah B. Prince 1 Shio Kobayashi 3 Chisayo Kozuka 1 4 Magnus Møller 5 Mette Bjerre 6 Jens Fuglsang 5 Emily Miele 1 ...

    Get Price
  • Cupric Ions Induce the Oxidation and Trigger the ...

    2013-6-3u2002·u2002Background Amyotrophic lateral sclerosis (ALS), partly caused by the mutations and aggregation of human copper, zinc superoxide dismutase (SOD1), is a fatal degenerative disease of motor neurons. Because SOD1 is a major copper-binding protein present at relatively high concentration in motor neurons and copper can be a harmful pro-oxidant, we want to know whether aberrant copper …

    Get Price
  • Perfluorochemical Liquids Enhance Delivery of Superoxide ...

    2006-7-1u2002·u2002Langenback EG, Davis JM, Robbins C, Sahgal N, Perry RJ, Simon SR 1999 Improved pulmonary distribution of recombinant human Cu/Zn superoxide …

    Get Price
  • Transduction of Cu, Zn-superoxide dismutase mediated by

    2006-6-22u2002·u2002This study was performed to investigate the transduction of a full-length superoxide dismutase (SOD) protein fused to transactivator of transcription (Tat) into human chondrocytes, and to determine the regulatory function of transduced Tat-SOD in the inflammatory cytokine induced catabolic pathway. The pTat-SOD expression vector was constructed to express the basic domain of HIV-1 Tat …

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  • Reduction in Mitochondrial Superoxide Dismutase

    2006-5-10u2002·u2002Alzheimer's disease (AD) is associated with accumulations of amyloid-β (Aβ) peptides, oxidative damage, mitochondrial dysfunction, neurodegeneration, and dementia. The mitochondrial antioxidant manganese superoxide dismutase-2 (Sod2) might protect against these alterations. To test this hypothesis, we inactivated one Sod2 allele ( Sod2 +/−) in human amyloid precursor protein (hAPP ...

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  • Myocardial Protective Effect of Extracellular Superoxide ...

    2014-2-15u2002·u2002Extracellular superoxide dismutase (ecSOD) binds to heparin sulfate proteoglycans on cellular surface as a unique scavenger of superoxide anions in the extracellular space . Many studies have shown that direct gene transfer of the cDNA encoding membrane-bound human ecSOD affords transient cardio-protective effect [ 3, 5 ].

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  • Increased 3‐nitrotyrosine and oxidative damage in mice ...

    Abstract Mutations in copper/zinc superoxide dismutase (SOD1) cause a subset of cases of autosomal dominant familial amyotrophic lateral sclerosis (FALS). Transgenic mice that express these point m...

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  • Superoxide Dismutase 1 Nanozyme for Treatment of Eye ...

    2015-12-1u2002·u2002Use of antioxidants to mitigate oxidative stress during ocular inflammatory diseases has shown therapeutic potential. This work examines a nanoscale therapeutic modality for the eye on the base of antioxidant enzyme, superoxide dismutase 1 (SOD1), termed 'nanozyme.' The nanozyme is produced by electrostatic coupling of the SOD1 with a cationic block copolymer, poly(L-lysine)-poly ...

    Get Price
  • The biophysics of superoxide dismutase-1 and

    Human and bovine SOD1 were each found to be composed of two sub-units of 16 kDa with strong interactions. This indicated that SOD1 is dimeric with high dimer affinity (Keele et al., Reference Keele, McCord and Fridovich 1971; Hartz and Deutsch, Reference …

    Get Price
  • Therapeutic effect of lecithinized superoxide dismutase on ...

    2010-3-1u2002·u2002idiopathic pulmonary fibrosis (IPF) is a progressive and devastating chronic lung condition with poor prognosis; the mean length of survival from the time of diagnosis is 2.8–4.2 years. IPF progresses insidiously and slowly, and acute exacerbation of IPF is a highly lethal clinical event (1, 4, 21, 36).Current agents for the treatment of IPF, such as steroids and immunosuppressors, have not ...

    Get Price
  • Reduction in Mitochondrial Superoxide Dismutase

    2006-5-10u2002·u2002Alzheimer's disease (AD) is associated with accumulations of amyloid-β (Aβ) peptides, oxidative damage, mitochondrial dysfunction, neurodegeneration, and dementia. The mitochondrial antioxidant manganese superoxide dismutase-2 (Sod2) might protect against these alterations. To test this hypothesis, we inactivated one Sod2 allele ( Sod2 +/−) in human amyloid precursor protein (hAPP ...

    Get Price
  • Wild-type Cu/Zn-superoxide dismutase is misfolded in ...

    2019-11-19u2002·u2002A subset of familial forms of amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene coding Cu/Zn-superoxide dismutase (SOD1). Mutant SOD1 proteins are susceptible to misfolding and abnormally accumulated in spinal cord, which is most severely affected in ALS. It, however, remains quite controversial whether misfolding of wild-type SOD1 is involved in more …

    Get Price
  • Placental superoxide dismutase 3 mediates benefits of ...

    Kusuyama et al. define a novel mechanism for placental transmission of improved metabolic health to offspring. SOD3 is identified as an exercise-induced and vitamin D-regulated placenta-derived protein that improves glucose homeostasis in offspring. SOD3 activates an AMPK/TET signaling axis resulting in epigenetic changes to metabolic genes in offspring liver.

    Get Price
  • i na r y Sciec Journal of Veterinary Science & et al ...

    2020-3-13u2002·u2002glutathione peroxidase (Se), catalase (Fe) and superoxide dismutase (Cu, Zn, and Mn) are also critical in protecting the internal cellular constituents from oxidative damage (Weiss, 2006). Superoxide Dismutase (SOD) Superoxide dismutase (SOD) was first isolated by Mann and Keilin [16] and thought to be a copper storage protein.

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  • Blood Pressure–Lowering by the Antioxidant Resveratrol Is ...

    2019-5-22u2002·u2002Human primary vascular SMC were cultured in medium 199 supplemented with 1% penicillin-streptomycin and 20% fetal bovine serum. SMC were maintained at 37 o C in a 20%O 2 /5%CO 2 incubator and grown on 12-well culture plates until 90% confluent (approximately 0.3 x 10 6 ) before experimental treatment.

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  • Home Page: Metabolism - Clinical and Experimental

    2021-9-30u2002·u2002Metabolism - Clinical and Experimental. Metabolism promotes excellence in research by publishing high-quality original research papers, fast-tracking cutting-edge papers, research brief reports, mini-reviews, and other special articles related to all aspects of human metabolism. Work considered for publication in Metabolism includes studies in ...

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  • Ferulic acid inhibits LPS-induced apoptosis in bovine ...

    2021-7-13u2002·u2002In bovine mammary epithelial cells (BMECs), a cascade of inflammatory reactions induced by lipopolysaccharide (LPS) has been shown to result in cell injury and apoptosis. The present study aims to reveal the protective effect of ferulic acid (FA) on LPS-induced BMEC apoptosis and explore its potential molecular mechanisms. First, we showed that FA had low cytotoxicity to BMECs and ...

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  • Oxidative stress in angiogenesis and vascular disease ...

    2013-12-3u2002·u2002Oxidative stress, which is defined as an imbalance between prooxidant and antioxidant systems, 7 can be both a cause and consequence of many vascular complications and serve as one of the biomarkers for these conditions. At the same time, well-controlled oxidative stress may be beneficial for angiogenesis during tissue repair.

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  • The biophysics of superoxide dismutase-1 and

    Human and bovine SOD1 were each found to be composed of two sub-units of 16 kDa with strong interactions. This indicated that SOD1 is dimeric with high dimer affinity (Keele et al., Reference Keele, McCord and Fridovich 1971; Hartz and …

    Get Price
  • OMIM Entry - * 147450 - SUPEROXIDE DISMUTASE 1; SOD1

    Barra et al. (1980) and Jabusch et al. (1980) independently determined the amino acid structure of human superoxide dismutase-1. The 153-residue protein shares approximately 82% homology with the bovine protein. Sherman et al. (1983) isolated clones corresponding to the human SOD1 gene. The deduced 153-residue protein has a calculated molecular mass of approximately 18.5 …

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  • Therapeutic effect of lecithinized superoxide dismutase on ...

    2010-3-1u2002·u2002idiopathic pulmonary fibrosis (IPF) is a progressive and devastating chronic lung condition with poor prognosis; the mean length of survival from the time of diagnosis is 2.8–4.2 years. IPF progresses insidiously and slowly, and acute exacerbation of IPF is a highly lethal clinical event (1, 4, 21, 36).Current agents for the treatment of IPF, such as steroids and …

    Get Price
  • Placental superoxide dismutase 3 mediates benefits of ...

    Kusuyama et al. define a novel mechanism for placental transmission of improved metabolic health to offspring. SOD3 is identified as an exercise-induced and vitamin D-regulated placenta-derived protein that improves glucose homeostasis in offspring. SOD3 activates an AMPK/TET signaling axis resulting in epigenetic changes to metabolic genes in offspring liver.

    Get Price
  • Effects of Manganese Superoxide Dismutase Silencing on ...

    Purpose: Advanced prostate cancer is first treated with androgen deprivation therapy. However, tumors become resistant to and grow despite castrate levels of testosterone. Growth and proliferation of CRPC is mediated by gain-of-function changes in the AR and AR reactivation. Expression of manganese superoxide dismutase (SOD2), which regulates cellular ROS, is …

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  • Wild-type Cu/Zn-superoxide dismutase is misfolded in ...

    2019-11-19u2002·u2002A subset of familial forms of amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene coding Cu/Zn-superoxide dismutase (SOD1). Mutant SOD1 proteins are susceptible to misfolding and abnormally accumulated in spinal cord, which is most severely affected in ALS. It, however, remains quite controversial whether misfolding of wild-type SOD1 …

    Get Price
  • Intravenous superoxide dismutase as a protective agent to ...

    2017-7-26u2002·u2002Positive-pressure mechanical ventilation is essential in assisting patients with respiratory failure in the intensive care unit and facilitating oxygenation in the operating room. However, it was also recognized as a primary factor leading to hospital-acquired pulmonary dysfunction, in which pulmonary oxidative stress and lung inflammation had been known to …

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  • SOD2 immunoexpression predicts lymph node metastasis

    2015-3-3u2002·u2002Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme in lung, gastric, colorectal, breast cancer and cervical cancer malignant tumors has been observed. Its relationship with inguinal lymph node metastasis in penile cancer is unknown.

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  • Chronic exposure to 12- O -tetradecanoylphorbol-13

    2007-7-25u2002·u2002Introduction. Manganese superoxide dismutase (MnSOD) is a mitochondrial antioxidant enzyme coded by the sod2 gene located on human chromosome 6q25.3 ( 1, 2).The human MnSOD gene ( sod2) is a single-copy gene consisting of five exons interrupted by four introns with typical splice junctions ( 3). Sod2 genes from human, bovine, rat and mouse share …

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  • Autologous Platelet Rich Plasma (Platelet Gel): An ...

    2020-10-13u2002·u2002human Umbilical Vein Endothelium) in vitro, protects catalase and superoxide dismutase when prepared using nanosecond pulsed electric fields rather than bovine thrombin and decreases the metalloproteinase MMP-2 and increases the metalloproteinase inhibitor TIMP-1 in H9c2 cells (Rattus norvegicus H9c2 cardiac myoblast cells) in vitro. Introduction

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